Risk factors associated with syphilis reinfection: an integrative review
DOI:
https://doi.org/10.31011/reaid-2024-v.98-n.3-art.2339Keywords:
Reinfection, Syphilis, Risk factors, Sexually transmitted infectionAbstract
This study aimed to evaluate the evidence on risk factors for reinfection of syphilis. This is an integrative review, conducted using the PRISMA protocol, through the following databases: Latin American and Caribbean Health Sciences Literature (LILACS) via the Virtual Health Library (VHL), US National Library of Medicine/National Institutes of Health (PubMed/MEDLINE), Web of Science, Scopus, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and EMBASE, where thirteen articles were rigorously selected. The main factors associated with syphilis reinfection were co-infection with the Human Immunodeficiency Virus (HIV) and Men who have Sex with Men (MSM). Other factors were also indicated, but less frequently, such as latent (asymptomatic) syphilis, age between 20 and 40, multiple sexual partners, among others. Considering the crucial role of specific populations as factors strongly associated with cases of syphilis reinfection, quality health education actions are needed in health institutions, by qualified health professionals. This review identifies decisive data for drawing up public strategies on the subject. The results elucidate the essential need for public health authorities to seek effective strategies to prevent re-infection with syphilis.
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References
World Health Organization. Global health sector strategies on, respectively, HIV, viral hepatitis and sexually transmitted infections for the period 2022-2030. 2022.
Marques VCPS, Lima RS, Farias AFC, Lima MWH, Neca CSM, Pereira RS, et al. Infecções sexualmente transmissíveis no sistema público de saúde: uma revisão bibliográfica. Revista Científica Multidisciplinar. 2022;3(5):1-8. DOI: https://doi.org/10.47820/recima21.v3i5.1500
Lasagabaster DA, Guerra LO. Syphilis. Enfermedades Infecciosas y Microbiología Clínica. 2019;37(6):398-404. DOI: https://doi.org/10.1016/j.eimc.2018.12.009
Sociedade Brasileira de Medicina Tropical. Sífilis: estudo genético revela que doença está de volta [Internet]. SBMT; c2023 [citado 2024 Maio 22]. Disponível em: https://sbmt.org.br/sifilis-estudo-genetico-revela-que-doenca-esta-de-volta/.
Ramos AN. Persistence of syphilis as a challenge for the Brazilian public health: the solution is to strengthen SUS in defense of democracy and life. Reports in Public Health. 2022;38(5):1-6. DOI: https://doi.org/10.1590/0102-311xen069022
Ministério da Saúde (BR). Boletim Epidemiológico: Sífilis. Brasília: Ministério da Saúde; 2022. 60p.
Forrestel AK, Kovarik CL, Katz KA. Sexually acquired syphilis: Historical aspects, microbiology, epidemiology, and clinical manifestations. J Am Acad Dermatol. 2020;82(1):1-14. DOI: https://doi.org/10.1016/j.jaad.2019.02.073
Mahono CK, Niode NJ. Secondary syphilis reinfection with suspected asymptomatic neurosyphilis. Indonesian Journal of Case Reports. 2023;1(2):35-8. DOI: https://doi.org/10.60084/ijcr.v1i2.119
Marchese V, Tiecco G, Storti S, Antoni MD, Calza S, Gulletta M, et al. Syphilis infections, reinfections and serological response in a large Italian sexually transmitted disease centre: a monocentric retrospective study. J Clin Med. 2022;11(24):1-12. DOI: https://doi.org/10.3390/jcm11247499
Tumalán-Gil OM, Ruiz-González V, García-Cisneros S, González-Rodriguez A, Herrera-Ortiz A, Olamendi-Portugal M, et al. igh incidence, reinfections, and active syphilis in populations attending a specialized HIV clinic in Mexico, a dynamic cohort study. Arch Sex Behav. 2023;52(2):783-791. DOI: https://doi.org/10.1007/s10508-022-02433-1
Kenyon C, Osbak KK, Crucitti T, Kestens L. Syphilis reinfection is associated with an attenuated immune profile in the same individual: a prospective observational cohort study. BMC Infect Dis. 2018 Sep 25;18(1):479. DOI: https://doi.org/10.1186/s12879-018-3399-8
Kochert AL. Reinfecção por sífilis adquirida: análise dos casos de Porto Alegre - 2013 a 2017 [Trabalho de Conclusão de Curso]. Porto Alegre: Universidade Federal do Rio Grande do Sul; 2018.
Jesus SJA. Synergy of the infection: a systematic review of public policies for control of syphilis in brazil. Rev Interfaces. 2021;9(2):1116-22. DOI: https://doi.org/10.16891/2317-434X.v9.e2.a2021.pp1116-1122
Whittemore R, Knafl K. The integrative review: updated methodology. J Adv Nurs. 2005;52(5):546-53. DOI: https://doi.org/10.1111/j.1365-2648.2005.03621.x
Stillwell SB, Fineout-Overholt E, Melnyk BM, Williamson KM. Evidence-based practice, step by step: searching for the evidence. Am J Nurs. 2010;110(5):41-7. DOI: https://doi.org/10.1097/01.NAJ.0000372071.24134.7e
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372(71):1-9. DOI: https://doi.org/10.1136/bmj.n71
Pastuszczak M, Bociąga-Jasik M, Sitko M, Wojas-Pelc A. HIV infection and sex in sex-on-premises venues are associated with a higher risk of syphilis reinfection among men who have sex with men. Postepy Dermatol Alergol. 2018;35(5):481-484. DOI: https://doi.org/10.5114/ada.2018.77238
Di Tullio F, Mandel VD, Cuomo G, Coppini M, Guaraldi G, Mussini C, et al. HIV and syphilis: incidence rate of coinfection and syphilis reinfection in a cohort of newly diagnosed HIV patients. Ital J Dermatol Venerol. 2022;157(2):158-163. DOI: https://doi.org/10.23736/S2784-8671.21.07042-0
Dolan G, Chauhan M, Foster K, Basta M, Bushby S, White C, et al. Factors associated with repeat diagnosis of syphilis in genitourinary medicine (GUM) clinic attendees in the North East of England, 2002-2014. Int J STD AIDS. 2018;29(8):790-799. DOI: https://doi.org/10.1177/0956462418757554
Pinho-Bandeira T, Ricoca Peixoto V, Dias S, Sá Machado R. Factors associated with coinfection and reinfection by chlamydia, gonorrhoea and syphilis in Portugal. 16th World Congress on Public Health. Eur J Public Health. 2020;30(Issue Supplement_5):v199. DOI: https://doi.org/10.1093/eurpub/ckaa165.539
Mischler-Gornostaeva K, Glatz M, Fehr J, Bosshard PP. Clinical presentation and serological diagnosis of syphilis reinfection in men living with HIV: a retrospective cohort study. Sex Transm Infect. 2022;98(5):341-45. DOI: https://doi.org/10.1136/sextrans-2020-054923
Roth JA, Franzeck FC, Balakrishna S, Lautenschlager S, Thurnheer MC, Trellu LT, et al. Repeated Syphilis Episodes in HIV-Infected Men Who Have Sex With Men: A Multicenter Prospective Cohort Study on Risk Factors and the Potential Role of Syphilis Immunity. Open Forum Infect Dis. 2020;7(1):1-7. DOI: https://doi.org/10.1093/ofid/ofaa019
Newman, DR, Matthias J, Rahman MM, Brantley A, Peterman TA. Repeat Syphilis Among HIV-Infected Men in Florida and Louisiana 2000-2018: Implications for Screening Recommendations. AIDS Patient Care STDS. 2021;35(11):435-440. DOI: https://doi.org/10.1089/apc.2021.0081
Jain J, Santos GM, Scheer S, Gibson S, Crouch PC, Kohn R, et al. Rates and Correlates of Syphilis Reinfection in Men Who Have Sex with Men. LGBT Health. 2017;4(3):232-6. DOI: https://doi.org/10.1089/lgbt.2016.0095
Almeida VC, Donalisio MR, Cordeiro R. Factors Associated with Reinfection of Syphilis in Reference Centers for Sexually Transmitted Infections. Rev. Saúde Publica. 2017;51(64):1-9. DOI: https://doi.org/10.1590/s1518-8787.2017051006432
Luo Z, Zhu L, Ding Y, Yuan J, Li W, Wu Q, et al. Factors Associated with Syphilis Treatment Failure and Reinfection: A Longitudinal Cohort Study in Shenzhen, China. BMC Infect. Dis. 2017;17(620):1-5. DOI: https://doi.org/10.1186/s12879-017-2715-z
Kenyon C, Osbak KK, Apers L. Repeat Syphilis Is More Likely to Be Asymptomatic in HIV-Infected Individuals: A Retrospective Cohort Analysis With Important Implications for Screening. Open Forum Infect Dis. 2018 Apr 28;5(6):1-3. DOI: https://doi.org/10.1093/ofid/ofy096
Ministério da Saúde (BR). Coordenação de Doenças Sexualmente Transmissíveis e Aids. Sífilis: estratégias para diagnóstico no Brasil. Brasília: Ministério da Saúde; 2010. 100 p.
Gaspar PM, Bigolin A, Neto JBA, Pereira EDS, Bazzo ML. Protocolo Brasileiro para Infecções Sexualmente Transmissíveis 2020: testes diagnósticos para sífilis. Epidemiol Serv Saude. 2021;30(Esp.1):1-13. DOI: https://doi.org/10.1590/s1679-4974202100006.esp1
Avelleira JCR, Bottino G. Sífilis: diagnóstico, tratamento e controle. An Bras Dermatol. 2006;81(2):111-26. DOI: https://doi.org/10.1590/S0365-05962006000200002
