SCOPING REVIEW PROTOCOL

 

STANDARD OF CARE FOR SICKLE CELL DISEASE IN CHILDREN AND ADOLESCENTS: A SCOPING REVIEW PROTOCOL

 

PADRÃO DE CUIDADO DA ANEMIA FALCIFORME PARA CRIANÇAS E ADOLESCENTES: PROTOCOLO DE REVISÃO DE ESCOPO

 

ESTÁNDAR DE ATENCIÓN PARA LA ANEMIA FALCIFORME EN NIÑOS Y ADOLESCENTES: PROTOCOLO DE REVISIÓN DE ALCANCE

 

https://doi.org/10.31011/reaid-2026-v.100-n.4-art.2728

 

1Laura de Souza Luiz

2Fernanda Pereira dos Santos

3Beatriz Sousa da Fonseca

4Heloiza Farias Caparroz

5Gabrieli Patricio Rissi

6Ieda Harumi Higarashi

 

1,2,3,4,5,6Universidade Estadual de Maringá. Maringá, PR, Brazil.

1E-mail: Laurasouzaluiz@hotmail.com. Orcid: https://orcid.org/0000-0002-3078-4999

2E-mail: fernanda.santos2337@gmail.com. Orcid: https://orcid.org/0000-0001-7564-8002

3E-mail: beatriz.sousa.fonseca@hotmail.com. Orcid: https://orcid.org/0000-0002-3469-2231

4E-mail: Heloiza.caparroz12@gmail.com. Orcid: https://orcid.org/0000-0001-8168-4413

5E-mail: gabrielirissi@gmail.com. Orcid: https://orcid.org/0000-0002-1702-4004

6E-mail: ieda1618@gmail.com. Orcid: https://orcid.org/0000-0002-4205-6841

 

Correspondimg Author

Heloiza Farias Caparroz

Universidade Estadual de Maringá. Programa de Pós-Graduação em Enfermagem - PSE/UEM, Avenida Colombo, 5.790 - Campus Universitário - Bloco 002, CEP 87020-900 - Maringá - Paraná – Brazil. E-mail: heloiza.caparroz12@gmail.com. Phone: (+55) 44 999790780

 

Submission: 30-01-2026

Approval: 07-10-2026

 

ABSTRACT

Introduction: Sickle cell anemia is a severe hereditary hemoglobinopathy, characterized by structural changes in red blood cells that result in episodes of vaso-occlusion, pain, and chronic tissue lesions, with significant repercussions on quality of life since childhood. In Brazil, it has a higher prevalence in the Northeast and Southeast regions, associated with African ancestry. Despite the advances resulting from neonatal screening and the National Policy for Comprehensive Care for People with Sickle Cell Disease, challenges persist related to access to specialized services, the training of health professionals, and the absence of standardized clinical protocols, which compromises the comprehensiveness of care, especially in primary care and emergency services. Objective: To map, in the global scientific literature, the standard of care for sickle cell anemia in children and adolescents, including clinical guidelines and care protocols. Method: This is a scoping review protocol conducted according to the methodology of the Joanna Briggs Institute and reported according to the recommendations of PRISMA-ScR. The sources of information will be PubMed/MEDLINE, Embase, Scopus, Web of Science, VHL, CINAHL, Cochrane Library, JBI Evidence Synthesis, and gray literature, such as Google Scholar, ResearchGate, and BDTD. The selection of studies will be carried out by two independent reviewers, with the support of the Rayyan software. Expected results: It is expected to identify and systematize guidelines, protocols, and recommendations related to the care of sickle cell anemia in children and adolescents, as well as to map knowledge gaps. Conclusion: The review may support the qualification of care practice and the strengthening of public policies aimed at the comprehensive care of this population.

Keywords: Anemia, Sickle Cell; Standard of Care; Comprehensive Health Care; Study Guides as Topic; Practice Guidelines as Topic.

 

RESUMO

Introdução: A anemia falciforme é uma hemoglobinopatia hereditária grave, caracterizada por alterações estruturais das hemácias que resultam em episódios de vaso-oclusão, dor e lesões teciduais crônicas, com repercussões significativas na qualidade de vida desde a infância. No Brasil, apresenta maior prevalência nas regiões Nordeste e Sudeste, associada à ancestralidade africana. Apesar dos avanços decorrentes da triagem neonatal e da Política Nacional de Atenção Integral às Pessoas com Doença Falciforme, persistem desafios relacionados ao acesso a serviços especializados, à capacitação dos profissionais de saúde e à ausência de protocolos clínicos padronizados, o que compromete a integralidade do cuidado, especialmente na atenção primária e nos serviços de urgência. Objetivo: Mapear, na literatura científica global, o padrão de cuidado da anemia falciforme em crianças e adolescentes, incluindo diretrizes clínicas e protocolos assistenciais. Método: Trata-se de um protocolo de revisão de escopo conduzido de acordo com a metodologia do Instituto Joanna Briggs e reportado conforme as recomendações do PRISMA-ScR. As fontes de informação serão PubMed/MEDLINE, Embase, Scopus, Web of Science, BVS, CINAHL, Cochrane Library, JBI Evidence Synthesis e literatura cinzenta, como Google Scholar, ResearchGate e BDTD. A seleção dos estudos será realizada por dois revisores independentes, com o apoio do software Rayyan. Resultados esperados: Espera-se identificar e sistematizar diretrizes, protocolos e recomendações relacionadas ao cuidado da anemia falciforme em crianças e adolescentes, bem como mapear lacunas do conhecimento. Conclusão: A revisão poderá subsidiar a qualificação da prática assistencial e o fortalecimento de políticas públicas voltadas ao cuidado integral dessa população.

Palavras-chave: Anemia Falciforme; Padrão de Cuidado; Assistência Integral à Saúde da Criança e do Adolescente; Guias como Assunto; Guias de Prática Clínica como Assunto.

 

RESUMEN

Introducción: La anemia falciforme es una hemoglobinopatía hereditaria grave, caracterizada por cambios estructurales en los glóbulos rojos que provocan episodios de vasooclusión, dolor y lesiones tisulares crónicas, con repercusiones significativas en la calidad de vida desde la infancia. En Brasil, tiene una mayor prevalencia en las regiones noreste y sureste, asociada a la ascendencia africana. A pesar de los avances derivados del cribado neonatal y la Política Nacional para la Atención Integral de las Personas con Anemia Falciforme, persisten desafíos relacionados con el acceso a servicios especializados, la formación de profesionales sanitarios y la ausencia de protocolos clínicos estandarizados, lo que compromete la atención integral, especialmente en atención primaria y servicios de urgencias. Objetivo: Mapear, en la literatura científica global, el estándar de atención para la anemia falciforme en niños y adolescentes, incluyendo guías clínicas y protocolos de cuidado.  Método: Este es un protocolo de revisión de alcance realizado según la metodología del Instituto Joanna Briggs y reportado según las recomendaciones de PRISMA-ScR. Las fuentes de información serán PubMed/MEDLINE, Embase, Scopus, Web of Science, VHL, CINAHL, Cochrane Library, JBI Evidence Synthesis y literatura gris, como Google Scholar, ResearchGate y BDTD/NDLTD. La selección de estudios será realizada por dos revisores independientes, con el apoyo del software Rayyan. Resultados esperados: Se espera identificar y sistematizar directrices, protocolos y recomendaciones relacionados con el cuidado de la anemia falciforme en niños y adolescentes, así como mapear las lagunas de conocimiento. Conclusión: La revisión puede apoyar la cualificación de la práctica de atención y el fortalecimiento de políticas públicas orientadas a la atención integral de esta población.

Palavras-chave: Anemia de Células Falciformes; Nível de Atención; Atención Integral de Salud; Guías como Asunto; Guías de Práctica Clínica como Asunto.

 

INTRODUCTION

Sickle cell anemia (SCA) is the homozygous (HbSS) and most severe form of sickle hemoglobinopathies, resulting from a homozygous mutation in the beta-globin gene (HBB, HbSS genotype). As a result of this structural alteration, red blood cells acquire a sickle shape, become rigid, and lose their ability to circulate freely, leading to vaso-occlusive phenomena, hemolysis, and chronic tissue injury. These manifestations compromise multiple organs and impact quality of life from early childhood, requiring constant and specialized care (1,2).

SCA represents one of the most prevalent genetic diseases worldwide, constituting a major global public health issue. Data from the Global Burden of Disease Study 2021 estimated 515,000 births of babies with sickle cell disease worldwide, of which 394,000 (76.5%) corresponded to the SS and Sβ° genotypes (severe form, including SCA), and 7.74 million people living with the disease globally, representing a 41.4% increase compared to 2000 (3).

The greatest burden is concentrated in Sub-Saharan Africa, accounting for 79% of births in 2021, but the disease is also relevant in the Americas and the Caribbean, with a 5.6% increase in birth incidence in Latin America and the Caribbean (3). In Brazil, it is estimated that between 25,000 and 50,000 people live with the homozygous or compound heterozygous form of the disease, with a higher prevalence in the Northeast and Southeast regions (4,5). This distribution is strongly associated with African ancestry, reflecting historical and structural inequalities, as evidenced by data from the Ministry of Health (6).

Although there have been advances in the normative field, such as the implementation of neonatal screening in 2001 fundamental for promoting early diagnosis and reducing morbidity and mortality in the country and the creation of the National Policy for Comprehensive Care of People with Sickle Cell Disease (PNAIPDF), the challenges in implementing public policies and organizing care are still significant. Difficulties in accessing specialized services, a lack of clinical knowledge on the part of healthcare teams, underreporting of cases, the absence of standardized protocols, and the fragmentation of the healthcare network remain frequent barriers (1,5,7).

Children and adolescents with SCA require continuous and comprehensive monitoring, with attention directed beyond clinical manifestations, focusing on the psychosocial impacts of the disease. The Family Health Strategy (ESF) acts as the main gateway to the Unified Health System (SUS), being a strategic point for strengthening Primary Health Care (PHC) and playing a central role in the longitudinal follow-up of children and adolescents with SCA. However, many healthcare professionals still report feeling unprepared to deal with the condition, which compromises continuous and effective care (1). Furthermore, emergency services lack specific protocols for the management of sickle cell crises in childhood, resulting in inadequate or delayed approaches (8).

Furthermore, there is a scarcity of standardized clinical protocols aimed at the management of acute complications and systematized multidisciplinary care in emergency and primary care services, such as the management of sickle cell crises in childhood, resulting in inadequate or delayed approaches (7,8). This scenario highlights the need for intersectoral actions that promote equity in the care of this population, especially in light of the racial and social inequalities that permeate the history of the disease in Brazil (4).

A preliminary literature search was conducted to verify the existence of previously published scoping reviews or systematic reviews on the topic. This exploratory search was conducted in databases such as PubMed/MEDLINE and the Virtual Health Library (VHL), using terms related to sickle cell disease, healthcare, clinical guidelines, and care protocols.

Review studies addressing specific aspects of sickle cell disease, such as clinical management, complications, quality of life, and health policies, were identified. However, no scoping reviews were found focusing on mapping clinical guidelines, care protocols, and standards of care specifically directed at children and adolescents with sickle cell disease, highlighting a knowledge gap and reinforcing the relevance of the present protocol.

The present review is justified by the convergence of gaps that compromise the quality and continuity of care, considering: the fragmentation of care across primary, emergency, and specialized services; the scarcity of standardized protocols for the management of SCA in childhood; and the high mortality risk in children with sickle cell anemia. This highlights the need to understand the coverage of existing protocols and to provide a basis for the integration of care actions directed at this population.

Given this context, this scoping review protocol aims to map the standard of care for sickle cell anemia in children and adolescents in the global scientific literature, including clinical guidelines and care protocols, in order to identify advances, gaps, and possibilities for improving healthcare.

METHODS

Study type, protocol, and registration

This is a scoping review protocol conducted based on the methodology proposed by the Joanna Briggs Institute (JBI) for the conduct of scoping reviews. The development of the protocol will follow the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) (9-10). The protocol was previously registered on the Open Science Framework (OSF) under the access DOI: https://doi.org/10.17605/OSF.IO/HB6VP.

The choice of a scoping review is justified as it is a methodological approach designed to map and synthesize the key concepts and available evidence in a given field of knowledge, as well as to examine the extent of research and identify gaps in the scientific literature (11).

Research question

The formulation of the research question and the structuring of the inclusion criteria were based on the PCC mnemonic (Population, Concept, and Context), defined as: (1) Population (P) – Children and adolescents (aged 0 to under 18 years) with a confirmed diagnosis of sickle cell anemia (HbSS genotype); (2) Concept (C) – Standard of care, encompassing clinical practice guidelines, care protocols, technical manuals, and institutional recommendations; (3) Context (C) – Global scientific literature and official documents, with no restrictions regarding geographical location or level of healthcare.

Based on these elements, the guiding research question was defined as: “What exists in the global literature regarding the standard of care for sickle cell anemia, including clinical guidelines and protocols, for children and adolescents?”.

Eligibility criteria

The eligibility criteria were defined based on the PCC framework and document typology. Publications focusing on the population of children and adolescents aged 0 to under 18 years diagnosed with SCA, encompassing the HbSS genotype, will be included. Regarding the concept, studies and documents addressing the standard of care for SCA will be considered, encompassing clinical practice guidelines, care protocols, technical manuals, public policies, and health recommendations. Concerning the context, the search will cover the global scientific literature, without any geographical delimitation or restriction regarding the level of healthcare. Primary studies with quantitative, qualitative, and mixed-methods approaches, secondary studies, and institutional grey literature produced by government agencies or scientific societies will be eligible, with no filters applied for publication period or language.

Conversely, documents that address sickle cell disease or other hemoglobinopathies broadly and generically, without presenting a specific sub-analysis or stratification for SCA, will be excluded. Publications in which care protocols or guidelines are not clearly and sufficiently described for data extraction will also be disregarded, as well as editorials, letters to the editor, conference abstracts, commentaries, book chapters, and articles based exclusively on expert opinion without normative or institutional endorsement.Serão incluídos na análise final apenas estudos com texto integral disponível.

If any eligible document is not directly accessible in full text within the databases or institutional repositories, up to three attempts will be made to contact the corresponding author via email over a three-week period. If there is no response or the file is not made available after this period, the study will be definitively excluded due to full-text unavailability (11).

Information sources

Searches will be conducted in the following indexed bibliographic databases: PubMed/MEDLINE, Excerpta Medica Database (EMBASE), Scopus, Web of Science, Virtual Health Library (VHL), Latin American and Caribbean Health Sciences Literature (LILACS via VHL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Library, and JBI Evidence Synthesis. Additionally, grey literature and institutional repositories will be consulted to map theses, dissertations, and guidelines not formally published, encompassing Google Scholar (evaluating the first 200 results sorted by relevance), ResearchGate, and the Brazilian Digital Library of Theses and Dissertations (BDTD)/Networked Digital Library of Theses and Dissertations (NDLTD).

To expand the retrieval of relevant articles, backward and forward citation searches will be conducted by examining the reference lists of the included studies and identifying subsequent citations. Institutional repositories and academic networks will also be consulted to locate full texts. No filters for publication date or study type will be applied, ensuring a comprehensive approach.

Search strategy

For the search strategy, a three-step approach will be employed: (1) an initial exploratory search in PubMed, VHL, and EMBASE, accessed via the CAPES Periodicals Portal through the Federated Academic Community (CAFe), aimed at identifying controlled descriptors in the Medical Subject Headings (MeSH), Health Sciences Descriptors (DeCS), and Emtree vocabularies, as well as keywords and free-text terms present in the titles and abstracts of related publications. The structured preliminary strategy (Table 1) for PubMed combines the following blocks of terms:

Table 1 – Preliminary search strategy in PubMed

IS*

Search strategy

Retrieved articles

PubMed

(Child OR "Child, Preschool" OR "Infant" OR "Newborn" OR "ADOLEC" OR Adolescent) AND ("Anemia, Sickle Cell") AND (“Standard of Care” OR “Evidence-Based Practice” OR “Guidelines as Topic” OR “Practice Guideline” OR “eHealth Strategies” OR “Clinical Protocols” OR “Health Planning Guidelines” OR “Practice Guidelines as Topic” OR “Guideline Adherence”)

259

*IS: Information source.

Source: Prepared by the authors.

 

(2) Development and application of the final search strategies combining controlled descriptors and keywords using the Boolean operators AND and OR, with appropriate qualifier adaptations for each database. The detailed syntax adapted for each of these sources is described in Appendix I; and (3) a complementary search in the grey literature, including Google Scholar, ResearchGate, the Brazilian Digital Library of Theses and Dissertations (BDTD), and the Networked Digital Library of Theses and Dissertations (NDLTD).

Study selection

The records retrieved from all information sources will be exported to a reference manager and imported into the Rayyan Intelligent Systematic Review software, where the automated and manual identification and removal of duplicates will be performed (12). The selection of publications will occur in two blind and independent phases (blind mode), conducted by two reviewers. The first phase will consist of screening and reading the titles and abstracts of all retrieved records.

The second phase will comprise the full-text reading of all publications pre-selected in the previous stage to confirm final eligibility based on the previously established criteria (full-text screening). To ensure standardization and consistency in the application of the inclusion and exclusion criteria between the reviewers, a prior calibration step will be conducted on a random sample of 25 retrieved publications.

Prior to the start of formal screening, the two reviewers will conduct a calibration test on a random sample of 25 publications. A minimum absolute agreement rate of 75% between the reviewers will be established as a satisfactory threshold to validate the calibration. If the achieved percentage is lower, the eligibility criteria will be discussed, aligned, and re-evaluated on a new sample of 25 records until the established target is reached (11).

Any disagreements between the two reviewers arising during Phase 1 or Phase 2 will initially be addressed through consensus meetings for a joint re-evaluation of the document. If the divergence persists after discussion, the definitive inclusion or exclusion of the study will be deliberated and decided by a third reviewer.

Data extraction and analysis

The extraction of information from the eligible publications will be conducted independently by the two reviewers using a standardized form structured according to the JBI guidelines (Appendix II). The data collection instrument will undergo a prior pilot test on two selected studies to verify its clarity, comprehensiveness, and applicability in capturing the variables of interest.

Data synthesis and presentation of results

Data analysis will be conducted descriptively, with thematic categorization of the extracted contents, allowing the identification of recurrences, gaps, and contextual variations among the mapped evidence.

EXPECTED RESULTS

The results will be presented through tables, charts, flowcharts, and thematic maps, according to the nature of the identified evidence. These visual representations will be accompanied by a narrative synthesis aimed at contextualizing the findings, highlighting the most relevant evidence, and identifying knowledge gaps. The discussion of the results will consider their implications for policymaking, the improvement of care practices, and the management of health services, especially in the care of children and adolescents with SCA.

REFERENCES

1.  Leal ALR, Lima CA, Mangueira SAL, Falci DM, Canôas SS. Atenção à pessoa com anemia falciforme no contexto da Estratégia Saúde da Família: a ótica dos profissionais. Cad. Saúde Colet. 2024;32(1):e32010576. doi: https://doi.org/10.1590/1414-462X202432010576

2. Silva GS, Sousa BVN, Oliveira EF, Martins KD, Jesus VS, Nascimento OC. Busca pelo tratamento da crise álgica na doença falciforme: concepções das genitoras. Rev Bras Promoç Saúde. 2021;34:10989. doi: https://doi.org/10.5020/18061230.2021.10989

3. GBD 2021 Sickle Cell Disease Collaborators. Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000-2021: a systematic analysis from the Global Burden of Disease Study 2021. Lancet Haematol. 2023 Aug;10(8):e585-e599. doi: 10.1016/S2352-3026(23)00118-7

4. Mota CS, Lira AS, Queiroz MCA, Santos MPA, et al. Àgô Sankofa: um olhar sobre a trajetória da doença falciforme no Brasil nos últimos 20 anos. Ciênc Saúde Colet. 2024;29:e06772023. doi: https://doi.org/10.1590/1413-81232024293.06772023

5. Secretaria da Saúde do Estado da Bahia (BR). Boletim Epidemiológico de Doença Falciforme, nº 01, nov. 2023 [Internet]. Salvador: SESAB; 2023 [citado 2025 jun 23]. Disponível em: https://www.ba.gov.br/saude/sites/site-sesab/files/migracao_2024/arquivos/wp-content/uploads/2023/11/boletimEpidemiologicoDoencaFalciformeNo01_nov2023-2.pdf

6. Ministério da Saúde (BR). Secretaria de Vigilância em Saúde e Ambiente. Boletim Epidemiológico: saúde da população negra. Número especial, vol. 1, out. 2023 [Internet]. Brasília: Ministério da Saúde; 2023 [citado 2025 jun 23]. Disponível em: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/boletins/epidemiologicos/especiais/2023/boletim-epidemiologico-saude-da-populacao-negra-numero-especial-vol-1-out.2023/

7. Teixeira JBC, Morais AC, Santos VEP, Santos DV, Carvalho ESS, Miranda JOF, et al. Protocolo de enfermagem à criança com doença falciforme na emergência: uma abordagem convergente-assistencial. Rev Bras Enferm. 2022;75(Suppl 2):e20210908. doi: https://doi.org/10.1590/0034-7167-2021-0908

8. Nascimento LCN, Souza TV, Oliveira ICS, Morais RCM, Andrade MAC. Internalização do cuidado: um estudo qualitativo com escolares que convivem com a doença falciforme. Esc Anna Nery. 2021;25(1):e20190337. doi: https://doi.org/10.1590/2177-9465-EAN-2019-0337

9. Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 2018;169(7):467–73. doi: https://doi.org/10.7326/M18-0850

10. Peters MDJ, Godfrey C, McInerney P, Munn Z, Tricco AC, Khalil H. Scoping reviews (2020 version). In: Aromataris E, Munn Z, editors. JBI Manual for Evidence Synthesis. Adelaide: JBI; 2020. Chapter 11. doi: https://doi.org/10.46658/JBIMES-20-12

11. Peters MDJ, Marnie C, Tricco AC, Pollock D, Munn Z, Alexander L, et al. Updated methodological guidance for the conduct of scoping reviews. JBI Evid Synth. 2020;18(10):2119–26. doi: https://doi.org/10.11124/JBIES-20-00167

12. Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, and Ahmed Elmagarmid. Rayyan — a web and mobile app for systematic reviews. Systematic Reviews. 2016; 5:210, DOI: 10.1186/s13643-016-0384-4.

Funding sources

This work was supported by the National Council for Scientific and Technological Development (CNPq) – Brazil – Grant No. 140522/2026-3.

Conflict of interest statement

None to declare.

Data availability statement

All content underlying the article is contained within the manuscript.

Authorship criteria (author contributions)

Conception and design of the study; or acquisition, analysis, or interpretation of research data: Luiz, LDS; Santos, FP; Fonseca, BS; Rissi, GP.

Drafting or critical revision of the manuscript for important intellectual content: Luiz, LDS; Santos, FP; Fonseca, BS; Rissi, GP; Higarashi, IH.

Final approval of the version to be published: Luiz, LDS; Santos, FP; Fonseca, BS; Caparroz, HF; Rissi, GP; Higarashi, IH.

Agreement to be accountable for all aspects of the work, including ensuring its accuracy and integrity: Luiz, LDS; Santos, FP; Fonseca, BS; Caparroz, HF; Rissi, GP; Higarashi, IH.

Scientific Editor: Ítalo Arão Pereira Ribeiro. ORCID: https://orcid.org/0000-0003-0778-1447

Rev Enferm Atual In Derme 2026;100(4): e026114                  

 

APPENDICES

Appendix I: Search strategy

 

 

Objective

To map, in the global literature, the standard of care for sickle cell anemia, including clinical guidelines and protocols, for children and adolescents.

P

C

C

Extraction

Children and adolescents

Standard of care for sickle cell anemia

Global level of healthcare

Conversion

Child

Child, Preschool

Infant

Newborn

ADOLEC

Adolescent

 

Standard of Care

 Evidence-Based Practice Guidelines as Topic

Practice Guideline

Clinical Protocols

Health Planning Guidelines

Practice Guidelines as Topic

Guideline Adherence

Anemia, Sickle Cell

-

Combination

MESH

Child

Children

Child, Preschool

Preschool Child

Children, Preschool

Preschool Children

Infant

Infant*

Infant, Newborn

Infant*, Newborn

Newborn Infant*

Neonate*

Newborn*

Adolescent

Adolescent*

Adolescence

Adolescent*, Female

Female Adolescent*

Adolescent*, Male

Male Adolescent*

Youth*

Teen*

Teenager*

 

MESH

Standard of Care

Care Standard*

Standard* of Care

Evidence-Based Practice

Evidence Based Practice

Evidence-Based Health Care

Evidence-Based Health Care*

Health Care*, Evidence-Based

Evidence Based Healthcare

Evidence-Based Healthcare*

Healthcare, Evidence-Based

Healthcare*, Evidence-Based

Evidence Based Management, Healthcare

Evidence Based Management, Health Care

Evidence-Based Health Care Management

Evidence-Based Healthcare Management

Guidelines as Topic

Guidelines as Topics

Practice Guideline

Clinical Practice Guideline

Clinical Guideline*

Treatment Guideline

Intervention Guideline

Therapeutic Guideline

Guideline

Clinical Protocols

Clinical Protocol

Protocol*, Clinical

Treatment Protocol*

Protocol*, Treatment

Clinical Research Protocol

Protocol*, Clinical Research

Research Protocol, Clinical

Clinical Research Protocol*

Research Protocol*, Clinical

Health Planning Guidelines

Guideline*, Health Planning

Health Planning Guideline

Planning Guideline*, Health

Guideline* for Health Planning

Recommendation*, Health Planning

Health Planning Recommendation

Health Planning Recommendation*

Planning Recommendation*, Health

Recommendation, Health Planning

Practice Guidelines as Topic

Clinical Guidelines as Topic

Best Practice*

Guideline Adherence

Adherence, Guideline

Institutional Adherence

Adherence, Institutional

Policy Compliance

Compliance, Policy

Protocol Compliance

Compliance, Protocol

 

Anemia, Sickle Cell

Anemias, Sickle Cell

Sickle Cell Anemia*

Hemoglobin S Disease

Disease, Hemoglobin S

Hemoglobin S Disease*

Sickle Cell Disease

Cell Disease*, Sickle

Sickle Cell Disease*

Sickle Cell Disorder*

Cell Disorder*, Sickle

Sickle Cell Disorder

Sickling Disorder Due to Hemoglobin S

HbS Disease

Sickle Cell Anemia

MESH

 

-

EMTREE

'child' OR ‘children' OR 'child' OR 'child, preschool' OR 'pre-school child' OR 'infant' OR 'newborn’ OR 'teenager' OR 'adolescent'

EMTREE

'standard of care' OR 'standards of care' OR 'evidence based' OR 'evidence-based practice' OR 'evidence based practice' OR 'guidelines' OR 'guidelines as topic' OR 'practice guidelines' OR 'practice guidelines as topic' OR 'practice guideline' OR 'clinical protocols' OR 'clinical protocol' OR ‘protocol’ OR ‘guideline adherence’

 

‘anemia sickle cell in infancy and childhood’ OR ‘anemia sickle cell in infant and child’ OR 'anaemia, sickle cell' OR 'anemia, sickle cell' OR 'sickle anaemia' OR 'sickle anemia' OR 'sickle cell anaemia' OR 'sickle cell disease' OR 'sickle cell disorder' OR 'SS disease (sickle cell)' OR 'sickle cell anemia'

EMTREE

-

DECS

Criança OR

Child OR

Niño OR

Enfant OR “Pré-Escolar”

OR “Child, Preschool”

OR Preescolar

OR “Enfant d'âge préscolaire” OR Lactente OR Infant OR Lactante OR Nourrisson OR “Recém-Nascido” OR “Infant, Newborn” OR “Recién Nacido” OR “Nouveau-né” OR Adolescente OR Adolescent

Adolescente OR Adolescent

 

 

 

DECS

“Padrão de Cuidado” OR “Standard of Care” OR “Nivel de Atención” OR “Norme de soins” OR “Prática Clínica Baseada em Evidências” OR “Evidence-Based Practice” OR “Práctica Clínica Basada en la Evidencia” OR “Pratique factuelle” OR “Guias como Assunto” OR “Guidelines as Topic” OR “Guías como Asunto” OR “Recommandations comme sujet” OR “Diretrizes para o Planejamento em Saúde” OR “Health Planning Guidelines” OR “Directrices para la Planificación en Salud” OR “Directives de santé publique” OR “Guia de Prática Clínica” OR “Practice Guideline” OR “Guía de Práctica Clínica” OR “Guide de bonnes pratiques” OR Guia OR Guideline OR Guía OR Directives OR “Protocolos Clínicos” OR “Clinical Protocols” OR “Protocolos Clínicos” OR “Protocoles cliniques” OR “Guias de Prática Clínica como Assunto” OR “Practice Guidelines as Topic” OR “Guías de Práctica Clínica como Asunto” OR “Guides de bonnes pratiques cliniques comme sujet” OR “Fidelidade a Diretrizes” OR “Guideline Adherence” OR “Adhesión a Directriz” OR “Adhésion aux directives”

 

AND

 

“Anemia Falciforme” OR “Anemia, Sickle Cell” OR “Anemia de Células Falciformes” OR Drépanocytose

 

DECS

Construction

MESH

(Child) OR (Children) OR (Child, Preschool) OR (Preschool Child) OR (Children, Preschool) OR (Preschool Children) OR (Infant) OR (Infant*) OR (Infant, Newborn) OR (Infant*, Newborn) OR (Newborn Infant*) OR (Neonate*) OR (Newborn*) OR (Adolescent) OR (Adolescent*) OR (Adolescence) OR (Adolescent*, Female) OR (Female Adolescent*) OR (Adolescent*, Male) OR (Male Adolescent*) OR (Youth*) OR (Teen*) OR (Teenager*)

MESH

(Standard of Care) OR (Care Standard*) OR (Standard* Care) OR (Evidence-Based Practice) OR (Evidence Based Practice) OR (Evidence-Based Health Care) OR (Evidence Based Health Care) OR (Evidence-Based Health Care*) OR (Health Care*, Evidence-Based) OR (Evidence-Based Healthcare) OR (Evidence Based Healthcare) OR (Evidence-Based Healthcare*) OR (Healthcare, Evidence-Based) OR (Healthcare*, Evidence-Based) OR (Evidence Based Management, Healthcare) OR (Evidence Based Management, Health Care) OR (Evidence Based Health Care Management) OR (Evidence Based Healthcare Management) OR (Guidelines as Topic) OR (Guidelines as Topics) OR (Practice Guideline) OR (Clinical Practice Guideline) OR (Clinical Guideline*) OR (Treatment Guideline) OR (Intervention Guideline) OR (Therapeutic Guideline) OR (Guideline) OR (Clinical Protocols) OR (Clinical Protocol) OR (Protocol*, Clinical) OR (Treatment Protocol*) OR (Protocol*, Treatment) OR (Clinical Research Protocol) OR (Protocol*, Clinical Research) OR (Research Protocol, Clinical) OR (Clinical Research Protocol*) OR (Research Protocol*, Clinical) OR (Health Planning Guidelines) OR (Guideline*, Health Planning) OR (Health Planning Guideline) OR (Planning Guideline*, Health) OR (Guideline* Health Planning) OR (Recommendation*, Health Planning) OR (Health Planning Recommendation) OR (Health Planning Recommendation*) OR (Planning Recommendation*, Health) OR (Recommendation, Health Planning) OR (Practice Guidelines as Topic) OR (Clinical Guidelines as Topic) OR (Best Practice*) OR (Guideline Adherence) OR (Adherence, Guideline) OR (Institutional Adherence) OR (Adherence, Institutional) OR (Policy Compliance) OR (Compliance, Policy) OR (Protocol Compliance) OR (Compliance, Protocol)

 

(Anemia, Sickle Cell) OR (Anemias, Sickle Cell) OR (Sickle Cell Anemias) OR (Hemoglobin S Disease) OR (Disease, Hemoglobin S) OR (Hemoglobin S Diseases) OR (Sickle Cell Disease) OR (Hemoglobin S Disease) OR (Disease, Hemoglobin S) OR (Hemoglobin S Diseases) OR (Sickle Cell Disease) OR (Cell Disease, Sickle) OR (Cell Diseases, Sickle) OR (Sickle Cell Diseases) OR (Sickle Cell Disorders) OR (Cell Disorder, Sickle) OR (Cell Disorders, Sickle) OR (Sickle Cell Disorder) OR (Sickling Disorder Due to Hemoglobin S) OR (HbS Disease) OR (Sickle Cell Anemia)

MESH

EMTREE

'child' OR ‘children' OR 'child' OR 'child, preschool' OR 'pre-school child' OR 'infant' OR 'newborn’ OR 'teenager' OR 'adolescent'

EMTREE

'standard of care' OR 'standards of care' OR 'evidence based' OR 'evidence-based practice' OR 'evidence based practice' OR 'guidelines' OR 'guidelines as topic' OR 'practice guidelines' OR 'practice guidelines as topic' OR 'practice guideline' OR 'clinical protocols' OR 'clinical protocol' OR ‘protocol’ OR ‘guideline adherence’ AND

 

‘anemia sickle cell in infancy and childhood’ OR ‘anemia sickle cell in infant and child’ OR 'anaemia, sickle cell' OR 'anemia, sickle cell' OR 'sickle anaemia' OR 'sickle anemia' OR 'sickle cell anaemia' OR 'sickle cell disease' OR 'sickle cell disorder' OR 'SS disease (sickle cell)' OR 'sickle cell anemia'

EMTREE

DECS

Criança OR

Child OR

Niño OR

Enfant OR “Pré-Escolar”

OR “Child, Preschool”

OR Preescolar

OR “Enfant d'âge préscolaire” OR Lactente OR Infant OR Lactante OR Nourrisson OR “Recém-Nascido” OR “Infant, Newborn” OR “Recién Nacido” OR “Nouveau-né” OR Adolescente OR Adolescent

Adolescente OR Adolescent

 

 

 

DECS

“Padrão de Cuidado” OR “Standard of Care” OR “Nivel de Atención” OR “Norme de soins” OR “Prática Clínica Baseada em Evidências” OR “Evidence-Based Practice” OR “Práctica Clínica Basada en la Evidencia” OR “Pratique factuelle” OR “Guias como Assunto” OR “Guidelines as Topic” OR “Guías como Asunto” OR “Recommandations comme sujet” OR “Diretrizes para o Planejamento em Saúde” OR “Health Planning Guidelines” OR “Directrices para la Planificación en Salud” OR “Directives de santé publique” OR “Guia de Prática Clínica” OR “Practice Guideline” OR “Guía de Práctica Clínica” OR “Guide de bonnes pratiques” OR Guia OR Guideline OR Guía OR Directives OR “Protocolos Clínicos” OR “Clinical Protocols” OR “Protocolos Clínicos” OR “Protocoles cliniques” OR “Guias de Prática Clínica como Assunto” OR “Practice Guidelines as Topic” OR “Guías de Práctica Clínica como Asunto” OR “Guides de bonnes pratiques cliniques comme sujet” OR “Fidelidade a Diretrizes” OR “Guideline Adherence” OR “Adhesión a Directriz” OR “Adhésion aux directives”

 

AND

 

“Anemia Falciforme” OR “Anemia, Sickle Cell” OR “Anemia de Células Falciformes” OR Drépanocytose

 

DECS

Database

Search Strategy

Retrieved Articles

PUBMED

18/09/2025

((((((((((((((((((((((((Child[MeSH Terms]) OR (Children[Title/Abstract])) OR (Child, Preschool[MeSH Terms])) OR (Preschool Child[Title/Abstract])) OR (Children, Preschool[Title/Abstract])) OR (Preschool Children[Title/Abstract])) OR (Infant[MeSH Terms])) OR (Infant*[Title/Abstract])) OR (Infant, Newborn[MeSH Terms])) OR (Infant*, Newborn[Title/Abstract])) OR (Newborn Infant*[Title/Abstract])) OR (Neonate*[Title/Abstract])) OR (Newborn*[Title/Abstract])) OR (Adolescent[MeSH Terms])) OR (Adolescent*[Title/Abstract])) OR (Adolescence[Title/Abstract])) OR (Adolescent*, Female[Title/Abstract])) OR (Female Adolescent*[Title/Abstract])) OR (Adolescent*, Male[Title/Abstract])) OR (Male Adolescent*[Title/Abstract])) OR (Youth*[Title/Abstract])) OR (Teen*[Title/Abstract])) OR (Teenager*[Title/Abstract])) AND (((((((((((((((((((((((((((((((((((((((((((((((((((((((Standard of Care[MeSH Terms]) OR (Care Standard*[Title/Abstract])) OR (Standard* of Care[Title/Abstract])) OR (Evidence-Based Practice[MeSH Terms])) OR (Evidence Based Practice[Title/Abstract])) OR (Evidence Based Health Care[Title/Abstract])) OR (Evidence-Based Health Care*[Title/Abstract])) OR (Health Care*, Evidence-Based[Title/Abstract])) OR (Evidence Based Healthcare[Title/Abstract])) OR (Evidence-Based Healthcare*[Title/Abstract])) OR (Healthcare, Evidence-Based[Title/Abstract])) OR (Healthcare*, Evidence-Based[Title/Abstract])) OR (Evidence Based Management, Healthcare[Title/Abstract])) OR (Evidence Based Management, Health Care[Title/Abstract])) OR (Evidence Based Health Care Management[Title/Abstract])) OR (Evidence Based Healthcare Management[Title/Abstract])) OR (Guidelines as Topic[MeSH Terms])) OR (Guidelines as Topics[Title/Abstract])) OR (Practice Guideline[MeSH Terms])) OR (Clinical Practice Guideline[Title/Abstract])) OR (Clinical Guideline*[Title/Abstract])) OR (Treatment Guideline[Title/Abstract])) OR (Intervention Guideline[Title/Abstract])) OR (Therapeutic Guideline[Title/Abstract])) OR (Guideline[MeSH Terms])) OR (Clinical Protocols[MeSH Terms])) OR (Clinical Protocol[Title/Abstract])) OR (Protocol*, Clinical[Title/Abstract])) OR (Treatment Protocol*[Title/Abstract])) OR (Protocol*, Treatment[Title/Abstract])) OR (Clinical Research Protocol[Title/Abstract])) OR (Protocol*, Clinical Research[Title/Abstract])) OR (Research Protocol, Clinical[Title/Abstract])) OR (Clinical Research Protocol*[Title/Abstract])) OR (Research Protocol*, Clinical[Title/Abstract])) OR (Health Planning Guidelines[MeSH Terms])) OR (Guideline*, Health Planning[Title/Abstract])) OR (Health Planning Guideline[Title/Abstract])) OR (Planning Guideline*, Health[Title/Abstract])) OR (Guideline* for Health Planning[Title/Abstract])) OR (Recommendation*, Health Planning[Title/Abstract])) OR (Health Planning Recommendation[Title/Abstract])) OR (Health Planning Recommendation*[Title/Abstract])) OR (Planning Recommendation*, Health[Title/Abstract])) OR (Recommendation, Health Planning[Title/Abstract])) OR (Practice Guidelines as Topic[MeSH Terms])) OR (Clinical Guidelines as Topic Best Practice*[Title/Abstract])) OR (Guideline Adherence[MeSH Terms])) OR (Adherence, Guideline[Title/Abstract])) OR (Institutional Adherence[Title/Abstract])) OR (Adherence, Institutional[Title/Abstract])) OR (Policy Compliance[Title/Abstract])) OR (Compliance, Policy[Title/Abstract])) OR (Protocol Compliance[Title/Abstract])) OR (Compliance, Protocol[Title/Abstract]))) AND (((((((((((((((Anemia, Sickle Cell[MeSH Terms]) OR (Anemias, Sickle Cell[Title/Abstract])) OR (Sickle Cell Anemia*[Title/Abstract])) OR (Hemoglobin S Disease[Title/Abstract])) OR (Disease, Hemoglobin S[Title/Abstract])) OR (Hemoglobin S Disease*[Title/Abstract])) OR (Sickle Cell Disease[Title/Abstract])) OR (Cell Disease*, Sickle[Title/Abstract])) OR (Sickle Cell Disease*[Title/Abstract])) OR (Sickle Cell Disorder*[Title/Abstract])) OR (Cell Disorder*, Sickle[Title/Abstract])) OR (Sickle Cell Disorder[Title/Abstract])) OR (Sickling Disorder Due to Hemoglobin S[Title/Abstract])) OR (HbS Disease[Title/Abstract])) OR (Sickle Cell Anemia[Title/Abstract]))

332

WOS

18/09/2025

#1 AND #2 AND #3

#3 ((((((((((((((TS=(Anemia, Sickle Cell)) OR TS=(Anemias, Sickle Cell)) OR TS=(Sickle Cell Anemia*)) OR TS=(Hemoglobin S Disease)) OR TS=(Disease, Hemoglobin S)) OR TS=(Hemoglobin S Disease*)) OR TS=(Sickle Cell Disease)) OR TS=(Cell Disease*, Sickle)) OR TS=(Sickle Cell Disease*)) OR TS=(Sickle Cell Disorder*)) OR TS=(Cell Disorder*, Sickle)) OR TS=(Sickle Cell Disorder)) OR TS=(Sickling Disorder Due to Hemoglobin S)) OR TS=(HbS Disease)) OR TS=(Sickle Cell Anemia)

#2 (((((((((((((((((((((((((((((((((((((((((((((((((((((TS=(Standard of Care)) OR TS=(Care Standard*)) OR TS=(Standard* of Care)) OR TS=(Evidence-Based Practice)) OR TS=(Evidence Based Practice)) OR TS=(Evidence Based Health Care)) OR TS=(Evidence-Based Health Care*)) OR TS=(Health Care*, Evidence-Based)) OR TS=(Evidence Based Healthcare)) OR TS=(Evidence-Based Healthcare*)) OR TS=(Healthcare, Evidence-Based)) OR TS=(Healthcare*, Evidence-Based)) OR TS=(Evidence Based Management, Healthcare)) OR TS=(Evidence Based Management, Health Care)) OR TS=(Evidence Based Healthcare Management)) OR TS=(Guidelines as Topic)) OR TS=(Guidelines as Topics)) OR TS=(Practice Guideline)) OR TS=(Clinical Practice Guideline)) OR TS=(Clinical Guideline*)) OR TS=(Treatment Guideline)) OR TS=(Intervention Guideline)) OR TS=(Therapeutic Guideline)) OR TS=(Guideline)) OR TS=(Clinical Protocols)) OR TS=(Clinical Protocol)) OR TS=(Protocol*, Clinical)) OR TS=(Treatment Protocol*)) OR TS=(Protocol*, Treatment)) OR TS=(Clinical Research Protocol)) OR TS=(Protocol*, Clinical Research)) OR TS=(Research Protocol, Clinical)) OR TS=(Clinical Research Protocol*)) OR TS=(Research Protocol*, Clinical)) OR TS=(Health Planning Guidelines)) OR TS=(Guideline*, Health Planning)) OR TS=(Health Planning Guideline)) OR TS=(Planning Guideline*, Health)) OR TS=(Guideline* for Health Planning)) OR TS=(Recommendation*, Health Planning)) OR TS=(Health Planning Recommendation)) AND TS=(Health Planning Recommendation*)) OR TS=(Planning Recommendation*, Health)) OR TS=(Recommendation, Health Planning)) OR TS=(Practice Guidelines as Topic)) OR TS=(Clinical Guidelines as Topic Best Practice*)) OR TS=(Guideline Adherence)) OR TS=(Adherence, Guideline)) OR TS=(Institutional Adherence)) OR TS=(Adherence, Institutional)) OR TS=(Policy Compliance)) OR TS=(Compliance, Policy)) OR TS=(Protocol Compliance)) OR TS=(Compliance, Protocol)

#1 ((((((((((((((((((((((TS=(Child)) OR TS=(Children)) OR TS=(Child, Preschool)) OR TS=(Preschool Child)) OR TS=(Children, Preschool)) OR TS=(Preschool Children)) OR TS=(Infant)) OR TS=(Infant*)) OR TS=(Infant, Newborn)) OR TS=(Infant*, Newborn)) OR TS=(Newborn Infant*)) OR TS=(Neonate*)) OR TS=(Newborn*)) OR TS=(Adolescent)) OR TS=(Adolescent*)) OR TS=(Adolescence)) OR TS=(Adolescent*, Female)) OR TS=(Female Adolescent*)) OR TS=(Adolescent*, Male)) OR TS=(Male Adolescent*)) OR TS=(Youth*)) OR TS=(Teen*)) OR TS=(Teenager*)

105

Cochrane

18/09/2025

#1           MeSH descriptor: [Child] explode all trees  

#2           MeSH descriptor: [Child, Preschool] explode all trees              

#3           MeSH descriptor: [Infant] explode all trees

#4           MeSH descriptor: [Adolescent] explode all trees

#5           MeSH descriptor: [Standard of Care] explode all trees

#6           MeSH descriptor: [Evidence-Based Practice] explode all trees

#7           MeSH descriptor: [Guidelines as Topic] explode all trees

#8           MeSH descriptor: [Clinical Protocols] explode all trees

#9           MeSH descriptor: [Practice Guidelines as Topic] explode all trees

#10         MeSH descriptor: [Guideline Adherence] explode all trees

#11         MeSH descriptor: [Anemia, Sickle Cell] explode all trees

#12         (#1 OR #2 OR #3 OR #4) AND (#5 OR #6 OR #7 OR #8 OR #9 OR #10) AND #11

 

1

CINAHL

18/09/2025

((Child) OR (Child, Preschool) OR (Infant) OR (Newborn) OR (ADOLEC) OR (Adolescent)) AND ((Standard of Care) OR (Evidence-Based Practice) OR (Guidelines as Topic) OR (Practice Guideline) OR (eHealth Strategies) OR (Clinical Protocols) OR (Health Planning Guidelines) OR (Practice Guidelines as Topic) OR (Guideline Adherence)) AND (Anemia, Sickle Cell)

488

EMBASE

18/09/2025

#19 AND #20 AND #21

#21 'anemia sickle cell'/exp OR 'sickle cell anemia'/exp OR 'sickle cell disease'/exp

#20 'guideline'/exp OR 'practice guideline'/exp OR 'clinical protocol'/exp

#19 'child'/exp OR 'children'/exp OR 'adolescent'/exp OR 'infant'/exp OR 'teenager'/exp

769

SCOPUS

18/09/2025

('child' OR 'children' OR 'child' OR 'child, preschool' OR 'pre-school child' OR 'infant' OR 'newborn' OR 'teenager' OR 'adolescent' ) AND ( 'standard of care' OR 'standards of care' OR 'evidence based' OR 'evidence-based practice' OR 'evidence based practice' OR 'guidelines' OR 'guidelines as topic' OR 'practice guidelines' OR 'practice guidelines as topic' OR 'practice guideline' OR 'clinical protocols' OR 'clinical protocol' OR 'protocol' OR 'guideline adherence' ) AND ( 'anemia sickle cell in infancy and childhood' OR 'anemia sickle cell in infant and child' OR 'anaemia, sickle cell' OR 'anemia, sickle cell' OR 'sickle anaemia' OR 'sickle anemia' OR 'sickle cell anaemia' OR 'sickle cell disease' OR 'sickle cell disorder' OR 'sickle cell anemia' )

20

BVS

18/09/2025

(criança OR child OR niño OR enfant OR "Pré-Escolar" OR "Child, Preschool" OR preescolar OR "Enfant d'âge préscolaire" OR lactente OR infant OR lactante OR nourrisson OR "Recém-Nascido" OR "Infant, Newborn" OR "Recién Nacido" OR "Nouveau-né" OR adolescente OR adolescent OR adolescente OR adolescent) AND ("Padrão de Cuidado" OR "Standard of Care" OR "Nivel de Atención" OR "Norme de soins" OR "Prática Clínica Baseada em Evidências" OR "Evidence-Based Practice" OR "Práctica Clínica Basada en la Evidencia" OR "Pratique factuelle" OR "Guias como Assunto" OR "Guidelines as Topic" OR "Guías como Asunto" OR "Recommandations comme sujet" OR "Diretrizes para o Planejamento em Saúde" OR "Health Planning Guidelines" OR "Directrices para la Planificación en Salud" OR "Directives de santé publique" OR "Guia de Prática Clínica" OR "Practice Guideline" OR "Guía de Práctica Clínica" OR "Guide de bonnes pratiques" OR guia OR guideline OR guía OR directives OR "Protocolos Clínicos" OR "Clinical Protocols" OR "Protocolos Clínicos" OR "Protocoles cliniques" OR "Guias de Prática Clínica como Assunto" OR "Practice Guidelines as Topic" OR "Guías de Práctica Clínica como Asunto" OR "Guides de bonnes pratiques cliniques comme sujet" OR "Fidelidade a Diretrizes" OR "Guideline Adherence" OR "Adhesión a Directriz" OR "Adhésion aux directives") AND ("Anemia Falciforme" OR "Anemia, Sickle Cell" OR "Anemia de Células Falciformes" OR drépanocytose)

333

JBI

18/09/2025

“Child” OR “Child, Preschool” OR Infant OR “Infant, Newborn” OR Adolescent; “Standard of Care” OR “Evidence Based Practice” OR “Guidelines as Topic” OR “Practice Guideline” OR “Guideline” OR “Clinical Protocols” OR “Health Planning Guidelines” OR “Practice Guidelines as Topic” OR “Guideline Adherence”; “Anemia, Sickle Cell”

1

TOTAL

 

2049

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Appendix II: Data extraction instrument

AXIS

EXTRACTION VARIABLE

STUDY IDENTIFICATION

Title

Authors/Issuing body

Publication year

Origin/Country

Language

Objectives

Study/document type

Methods

POPULATION

Profile of subjects and target of actions

CONCEPT

Preventive and prophylactic measures

Management of acute events and emergencies

Disease-modifying and maintenance therapies

Multidisciplinary care and care pathway

CONTEXT

Global care setting and healthcare systems

SYNTHESIS

Evidence, impact, and gaps